PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
see also LinkedIn
PUBLIC OUTREACH
On May 28, 2026, Prof. Guse, spokesperson of SFB1328, visited Hamburg Grammar School Johannes-Brahms-Gymnasium and co-taught four classes (grade 10;…
PUBLIC OUTREACH
Interested pupils (grade 12) from Hamburg Grammar School Johannes-Brahms-Gymnasium were informed regarding study programs in Medicine and Biomedical…
PUBLIC OUTREACH
On 6 May, Dr Anna Worthmann (project A19) visited second-term biology classes at the Süderelbe Grammar School in Hamburg. As part of the topic ‘Life…
JOURNAL OF CELL SCIENCE
Pablo Sáez (project A20) was featured on the cover of the Journal of Cell Science as an outstanding cell biologist and as part of the Scientific…
April 20, 2026
On April 20, 2026, thirty pupils from Hamburg Grammar School Johannes-Brahms-Gymnasium visited two lectures given by Prof. Guse, spokesperson of…
GUEST SPEAKER
ScienceAfternoon speaker Dr Giovanna Grimaldi, CNR @ Naples, Italy, presented novel data regarding the role of ADP-ribosylation and PARP enzymes…
For further announcements, see LinkedIn
LATEST PUBLICATION
Ottenheijm R, Winterberg K, Throm V, Malz M, Bukva M, Tsvilovskyy V, Medert R, Guse AH, Freichel M. JPT2/HN1L functions as an NAADP-binding protein in a cell-type-specific manner. Cell Calcium. 2026 May 27
Bi C, Schwermer F, Schäkel L, Mirza S, Baburi H, Riziki P, Schmies CC, Winzer R, Idris R, Rolshoven G, Schilling J, Luckenbach L, Pelletier J, Brusoni LS, Al Hroub H, Al Hamwi G, Lopez V, Ahmadsay A, Raulien L, Sylvester K, Sévigny J, Tolosa E, Guse AH, Müller CE. Nucleotide-Derived Competitive Inhibitors of Ectonucleotidase CD39─A Promising Extracellular Target for Immunotherapy of Cancer. J Med Chem. 2026 May 1.
Dobelmann C, Schmies CC, Rolshoven GW, Scortichini M, Wagner S, Isaak A, Idris RM, Dabel J, Grey L, Losenkova K, Moschütz S, Hroub HA, Keim A, Höppner S, Sandholm J, Boström P, Hollmén M, Sträter N, Hermann S, Yegutkin GG, Jacobson KA, Schelhaas S, Müller CE, Junker A. Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. Angew Chem Int Ed Engl. 2026 Mar 15:e22758.
Skenteris NT, Luttermann E, Nair S, Evangelakos I, Pujantell M, Eggers M, Hausmann F, Bérouti M, Padoan B, Flomm FJ, Claussen JM, Grünhagel B, Salfelder A, Beifuss B, Biskup S, Blümke P, Rading K, Hildebrandt H, Matschl U, Giesemann-Jansen S, Hennesen J, Nikolaev VO, Kutsche M, Kubisch C, Koch-Nolte F, Tomas NM, Tolosa E, Lütgehetmann M, Stahl FR, Hornung V, Bunders MJ, Schlein C, Topf M, Kötter I, Altfeld M. Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome. JCI Insight. 2026 Feb 23;11(4):e187422.
Weiden EM, Serianz Z, Klingl Y, Jörs S, Jaślan D, Keller M, Castro SP, Mkhitaryan M, Jeridi A, Briukhovetska D, Spix B, Scotto Rosato A, Agami A, Schiller HB, Rajan S, Schredelseker J, Fois G, Frick M, Kobold S, Klein M, Geisler F, Garcia-Fortanet J, Murphy LO, Bracher F, Wahl-Schott C, Gudermann T, Dietrich A, Biel M, Yildirim AÖ, Grimm C. TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition. EMBO J. 2026 Feb 19.
