PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
see also LinkedIn
SFB1328 Meeting Report: 3rd European Purine Meeting
From June 30 to July 3, 2026, the 3rd European Purine Meeting was held in Bordeaux, France. Five members of the SFB 1328, Björn-Ph. Diercks (A02),…
SITE-VISIT
On June 24, 2026, all members of SFB1328 'Adenine Nucleotides in Immunity and Inflammation' attended the dress rehearsal for the on-site visit of the…
AWARD
Maximilian Sandmann received a Poster Award at the FASEB NAD Metabolism Meeting 2026 in Melbourne, Florida, for his presentation on the development of…
PUBLIC OUTREACH
On June 10, 2026, Dr. Charlotte Schubert, Project A16, visited Hamburg Grammar School Johannes-Brahms-Gymnasium and co-taught 2 classes in…
PUBLIC OUTREACH
On May 28, 2026, Prof. Guse, spokesperson of SFB1328, visited Hamburg Grammar School Johannes-Brahms-Gymnasium and co-taught four classes (grade 10;…
PUBLIC OUTREACH
Interested pupils (grade 12) from Hamburg Grammar School Johannes-Brahms-Gymnasium were informed regarding study programs in Medicine and Biomedical…
For further announcements, see LinkedIn
LATEST PUBLICATION
Al Jawazneh A, Liebold I, Leyk S, Lanzloth C, Brackrock V, López-López T, Graute S, Aranda-Pardos I, Hamley M, Bahn J, Heeren J, Von Felden J, Lohse AW, Schramm C, Schwinge D, Sáez PJ, A-Gonzalez N, Huber S, Jacobs T, Adlung L, Worthmann A, Bosurgi L. Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis. J Exp Med. 2026 Jul 6;223(7):e20242079.
Schubert C, Lopes Fonseca R, Hadjilaou A, Vieira V, Degenhardt K, Seemann AL, Hakimy A, Sonner JK, Ludewig P, Magnus T, Schneider M, Müller CE, Hirnet, E, Friese MA. Neuroglial p2y1 receptor signalling differentially contributes to inflammatory neurodegeneration. Journal of Neuroinflammation, 2026 23(1):199, 2026
Ottenheijm R, Winterberg K, Throm V, Malz M, Bukva M, Tsvilovskyy V, Medert R, Guse AH, Freichel M. JPT2/HN1L functions as an NAADP-binding protein in a cell-type-specific manner. Cell Calcium. 2026 May 27
Bi C, Schwermer F, Schäkel L, Mirza S, Baburi H, Riziki P, Schmies CC, Winzer R, Idris R, Rolshoven G, Schilling J, Luckenbach L, Pelletier J, Brusoni LS, Al Hroub H, Al Hamwi G, Lopez V, Ahmadsay A, Raulien L, Sylvester K, Sévigny J, Tolosa E, Guse AH, Müller CE. Nucleotide-Derived Competitive Inhibitors of Ectonucleotidase CD39─A Promising Extracellular Target for Immunotherapy of Cancer. J Med Chem. 2026 May 1.
Dobelmann C, Schmies CC, Rolshoven GW, Scortichini M, Wagner S, Isaak A, Idris RM, Dabel J, Grey L, Losenkova K, Moschütz S, Hroub HA, Keim A, Höppner S, Sandholm J, Boström P, Hollmén M, Sträter N, Hermann S, Yegutkin GG, Jacobson KA, Schelhaas S, Müller CE, Junker A. Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. Angew Chem Int Ed Engl. 2026 Mar 15:e22758.
