Adenosine is a potent anti-inflammatory molecule generated by the ectonucleotidase CD73. In this publication Enja Schneider, Riekje Winzer et al. show that activated human CD8 T cells release CD73-containing extracellular vesicles which produce adenosine. This T cell-intrinsic mechanism of immune suppression contests the common paradigm that regulatory T cells must provide the whole machinery for adenosine production. This work was part of the A14 project (Tolosa/Gagliani) in close collaboration with projects A01, A05, A11 and A13