A13

A13: Summary

Adenine nucleclotides (AN) are important regulators of the tightness of the blood brain barrier (BBB) and of inflammation. In the proposed project, we will focus on the identification of the purine nucleotide metabolism machinery in the cellular compartments that are compromised in the course of stroke, namely BBB endothelial cells and microglia, and on targeting these components to manipulate the opening of the BBB and microglial inflammation.

Prof. Dr. Tim Magnus

Selected publications

 

  1. Magnus T, Gold R (2001) Microglial phagocytosis of apoptotic inflammatory T cells leads to downregulation of microglial immune activation. J Immunol 167:5004-5010.
  2. Magnus T, Wiendl H (2005) Microglial expression of the B7-costimulatory molecule B7-H1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. J Neurosci 25:2537-2546.
  3. Arumugam TV, Magnus T, Poosala S, Granger DN, Mattson MP (2006) Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 12:621623.
  4. Mattson MP, Magnus T (2006 ) Ageing and neuronal vulnerability. Nat Rev Neurosci 7:278-294.
  5. Gelderblom M, Magnus T (2012) Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood 120:3793-3802.
  6. Magnus T, Gerloff C (2012) The neurological syndrome in adults during the 2011 northern German E. coli serotype. Brain 135:1850-1859.
  7. Ludewig P, Magnus T*, Horst AK* (2013) Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Inhibits MMP-9-Mediated Blood-Brain-Barrier Breakdown in a Mouse Model for Ischemic Stroke. Circ Res 113:1013-1022.* equally contributing authors
  8. Gelderblom M, Magnus T (2013) Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis. Neurobiol Dis 59:177-182.
  9. Gelderblom M, Magnus T (2014) Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke. Stroke 45:3395-3402.
  10. Ludewig P., Magnus T (2017) Magnetic Particle Imaging for Real-time Perfusion Imaging in Acute Stroke. ACS Nano 11:10480-10488.

Our Team

Prof. Dr. Tim Magnus

Department of Neurology

University Medical Center Hamburg-Eppendorf (UKE)

Prof. Dr. Eva Tolosa

Insitute of Immunology

University Medical Center Hamburg-Eppendorf (UKE)

Dr. Björn Rissiek

Department of Neurology

University Medical Center Hamburg-Eppendorf (UKE)

M. Sc. Enja Schneider

Insitute of Immunology

University Medical Center Hamburg-Eppendorf (UKE)

Dr. Anne Rissiek

Insitute of Immunology

University Medical Center Hamburg-Eppendorf (UKE)

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de