INTRODUCTION MOVIE
PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
PUBLIC OUTREACH
Members of project A14 presented their research at the International Day of Immunology, in a poster session organized by the Hamburg Center for…
SPECIAL
Congratulations to now PD Dr. Björn Rissiek from Project Z02 for successfully finishing his Habilitation!
April 22, 2025
Prof. Guse project A01 of SFB1328 (Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf) spent two hours at…
CALL MD STIPENDS
Apply now for the Research Training Group of the SFB1328
In total 8 SCHOLARSHIPS FOR MEDICAL STUDENTS are available
APPLICATIONS UNTIL JUNE 13, 2025…
BOOK
Björn-Philipp Diercks, Project A02, edited the book on "T cell activation" in the Methods in Molecular Biology series. This book provides detailed,…
SPECIAL ISSUE
ACS Pharmacology & Translational Science is calling for papers for a virtual Special Issue on "Purinergic Signaling".
They are inviting scientists…
For further announcements see:
LATEST PUBLICATION
Müller CE, Bruzzone S, Guse AH. Editorial: Adenine nucleotides in immunity and inflammation. Front Immunol. 2025 Mar 12;16:1585484.
Asada N, Ginsberg P, Paust HJ, Song N, Riedel JH, Turner JE, Peters A, Kaffke A, Engesser J, Wang H, Zhao Y, Khatri R, Gild P, Dahlem R, Diercks BP, Das S, Ignatova Z, Huber TB, Prinz I, Gagliani N, Mittrücker HW, Krebs CF, Panzer U. The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells. Nat Immunol. 2025 Mar 6.
Lorenz H, Menzel S, Roshchyna N, Albrecht B, Gebhardt AJ, Schneider E, Haag F, Rissiek B, Oheim R, Koch-Nolte F, Winzer R, Tolosa E. ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells. Cell Mol Life Sci. 2024 Dec 18;82(1):6. doi: 10.1007/s00018-024-05539-y.
Gerlach F, Möckl F, Kovacevic D, Brock VJ, Winzer R, Meyer L, Lohr D, Woelk LM, Tolosa E, Werner R, Diercks BP. Imaging Initial Ca2+ Microdomains in Primary T Cells. J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/67075.
Krukenberg S, Möckl F, Weiß M, Dekiert P, Hofmann M, Gerlach F, Winterberg KJ, Kovacevic D, Khansahib I, Troost B, Hinrichs M, Granato V, Nawrocki M, Hub T, Tsvilovskyy V, Medert R, Woelk LM, Förster F, Li H, Werner R, Altfeld M, Huber S, Clarke OB, Freichel M, Diercks BP, Meier C, Guse AH. MASTER-NAADP: a membrane permeable precursor of the Ca2+mobilizing second messenger NAADP. Nat Commun. 2024 Sep 13;15(1):8008.
von Kalben L, Sauer J, Gee C, Hirnet D, Lohr C. Dopaminergic cAMP signaling in mouse olfactory bulb astrocytes. Neurochem Int. 2024 Oct;179:105828.
