Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
The international scientific community has lost its pioneer in purinergic signalling! Geoffrey Burnstock died on the 2nd of June 2020 at the age of 91 in Melbourne (Australia). Our Collaborative Research Centre SFB1328 on adenine nucleotides in immunity and inflammation is unconceivable without Geoff Burnstock’s seminal work. Several times it has been a privilege to have Geoff Burnstock as plenary speaker during international meetings organised by members of the SFB1328.
For further announcements see:
Highton, A. J., Diercks, B.-P., Möckl, F., Martrus, G., Sauter, J., Schmidt, A. H., Bunders, M. J., Körner, C., Guse, A. H., Altfeld, M., (2020). High Metabolic Function and Resilience of NKG2A-Educated NK Cells. Front. Immunol. 11, 2285, 2020
Guse, A. H. (2020) 25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter. Molecules. 2020 Sep 15;25(18):E4220
Diercks, B.-P. and Guse, A. H. (2020) Unexpected players for local calcium signals: STIM and ORAI proteins. Curr Opin Physiol 2020, 17:1–8
Fliegert, R., Riekehr, W. M., Guse, A. H. (2020). Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? Front. Immunol. 11:2018.
Ahmadi, P., Hartjen, P., Kohsar, M., Kummer, S., Schmiedel, S., Bockmann, J.-H., Fathi, A., Huber, S., Haag, F., Schulze zur Wiesch, J. (2020). Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes. Cells, 9, 1750.