Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
PAPER SCIENCE SIGNALING
Although NAADP was discovered already over 25 years ago, as the most potent Ca2+ mobilizing messenger, the mechanism of action is still unclear. In this SFB publication, we present a long-assumed binding protein for NAADP called Hn1l/Jpt2, which has essential role in activating primary T cells, hence the adaptive immune response.
NEW PRESIDENT OF THE ECS
At the recent general Assembly of the European Calcium Society Prof. Andreas Guse was announced as the new President of the ECS. Furthermore Geert Bultynck is replacing Jan Parys as General Secretary. Congratulations to both!!
For further announcements see:
Roggenkamp HG, Khansahib I, Hernandez C LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH (2021) HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation. Sci Signal 14(675):eabd5647
Diercks BP, Jensen HH, Chalmers SB, Coode E, Vaughan MB, Tadayon R, Sáez PJ, Davis FM, Brohus M (2021) The first junior European calcium society meeting: Calcium research across scales, kingdoms and countries. Biochim Biophys Acta Mol Cell Res 1868:118999
Fischer T, Prey J, Eschholz L, Rotermund N, Lohr C (2021) Norepinephrine-Induced Calcium Signaling and Store-Operated Calcium Entry in Olfactory Bulb Astrocytes. Front Cell Neurosci 15:639754
Schaltenberg N, John C, Heine M, Haumann F, Rinninger F, Scheja L, Heeren J, Worthmann A (2021) Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice. Front Cardiovasc Med 8:628235
Menzel S, Koudelka T, Rissiek B, Haag F, Meyer-Schwesinger C, Tholey A, Koch-Nolte F (2021) ADP-Ribosylation Regulates the Signaling Function of IFN-γ. Front Immunol 12:642545