• SFB 1328

    Adenine Nucleotides in Immunity and Inflammation

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB1328 Retreat 2021

    26th - 28th of May 2021


Next Science Afternoon

  • 12 Jun
    Science Afternoon 12.06.2024

    2.00 - 3.00pm meet the speaker for young Scientist N30 & PI meeting online

    3.00 - 3.45pm Guestspeaker

    Prof. Dr. Barbara M. Braunger

    UKE –…



For direct access to project movies please click on the following links: A01A02A03A04, A05A06, A07A10, A11A12A13, A14 and A15.


Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling. 

Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown. 

The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.


Very successful Frontiers Research Topic on "Adenine Nucleotides in Immunity and Inflammation"!! For further information and publications see Frontiers Research Topic.


Congratulations to Dr. Riekje Winzer (Project A14) for being awarded the "Heinrich Netheler-Promotionspreis für Molekularbiologie" by the Freundes- und Förderkreis des UKE! 


Congratulations to Prof. Dr. Julian Schulze zur Wiesch (Project A12) for being awarded, among others, with the "Preis der Deutschen Hochschulmedizin 2023"! The scientists from the university hospitals in Hamburg, Düsseldorf, Erlangen and Cologne were honored for the successful treatment of a patient suffering from leukemia and the HI virus.

For further announcements see:


Eden T, Schaffrath AZ, Wesolowski J, Stähler T, Tode N, Richter N, Schäfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall CM, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt AJ, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor CG, Hartlepp KF, Schleer H, Füner J, Tomas NM, Haag F, Rissiek B, Mann AM, Menzel S, Koch-Nolte F. Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire. Nat Commun. 2024 Jun 3;15(1):4728.

Wittek A, Steglich B, Casar C, Seiz O, Huber P, Ehlken H, Reher D, Wende S, Bedke T, Kempski J, Böttcher M, Bang C, Thingholm L, Krech T, Lohse AW, Sauter G, Rösch T, Franke A, Schramm C, Gagliani N, Pelczar P, Huber S. A Gradient of Intestinal Inflammation in Primary Sclerosing Cholangitis. Inflamm Bowel Dis. 2024 Jun 3;30(6):900-910.

Diercks BP. The importance of Ca2+ microdomains for the adaptive immune response. Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119710.

Nagel J, Törmäkangas O, Kuokkanen K, El-Tayeb A, Messinger J, Abdelrahman A, Bous C, Schiedel AC, Müller CE. Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist. Purinergic Signal. 2024 May 25.

Woo MS, Engler JB, Friese MA. The neuropathobiology of multiple sclerosis. Nat Rev Neurosci. 2024 May 24. 



University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de


Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de