PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
see also LinkedIn
PAPER
In total, 8 PIs from 5 different projects, headed by A01, just published in Science Signaling that NAADP production by DUOX2 is regulated by the…
PAPER
SFB1328 scientists, headed by A20, just published in Science Advances. Their model revealed an important trade-off affecting the optimal number of…
PAPER
SFB1328 scientists, headed by A12 and A15, just published in Nature Communications the discovery of an allosteric binding site for anthraquinones at…
PAPER
SFB1328 scientists, headed by A19 and A14 , just published in ACS Pharmacology & Translational Science special issue “Purinergic Signaling” how to…
December 02, 2025
Prof. Heeren, project A10 of SFB1328 (Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf), gave a…
SPECIAL
Congratulations to now PD Dr. Jakob Körbelin from Project A13 for successfully finishing his Habilitation!
For further announcements, see LinkedIn
LATEST PUBLICATION
Winterberg KJ, Schwentner V, Gu F, Möckl F, Li G, Bauche A, Etzold S, Rosche A, Weiß M, Thuille N, Förster F, Woelk L, Werner R, Kovacevic D, Fehse B, Kurelic R, Nawrocki M, Huber S, Mittrücker HW, Meier C, Müller CE, Baier G, Skålhegg BS, de Deken X, Wahl-Schott C, Mair T, Siebels B, Cugota Canals R, Odoardi F, Lodygin D, Flügel A, Nikolaev VO, Diercks BP, Guse AH. Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation. Sci Signal. 2026 Jan 13;19(920):eadp4326.
Liu J, Boix-Campos J, Ron JE, Kux JM, Oremek MEM, Rossi AG, Gov NS, Sáez PJ. Trade-off between branching and polarity controls decision-making during cell migration. Sci Adv. 2026 Jan 2;12(1):eads2734.
Nagel J, Namasivayam V, Weinhausen S, Sierra-Marquez J, Baqi Y, Al Musawi HAM, Abdelrahman A, Vaaßen VJ, Schlegel JG, Taplick L, Torp J, Kubicek J, Maertens B, Geyer M, Claff T, Nicke A, Hagelueken G, Müller CE. Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor. Nat Commun. 2025 Dec 4;16(1):10367.
Winzer R, Hiefner J, Hackbusch R, Link MA, Thomalla G, Tolosa E, Worthmann A. Reliable Determination of ATP and Its Metabolites by LC-MS Using Blood Collection Tubes with and without Ectonucleotidase Inhibitors. ACS Pharmacology & Translational Science. 2025 Nov 7;8(12):4326-4334.
Jaeckstein MY, Fischer AW, Rissiek B, Staehler T, Heine M, Behrens J, Mann O, Pfeifer A, Magnus T, Schlein C, Worthmann A, Scheja L, Koch-Nolte F, Heeren J. Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue. EMBO Rep. 2025 Nov 19.
