• SFB 1328

    Adenine Nucleotides in Immunity and Inflammation

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB1328 Retreat 2021

    26th - 28th of May 2021

    read more...

Next Science Afternoon

  • 16 Apr
    Science Afternoon 16.04.2025

    Guestspeaker 

    Prof. Günther Schmalzing, Molekulare Pharmakologie, Uniklinik RWTH Aachen

    "Structural basis of ion selectivity of the human P2X7…

INTRODUCTION MOVIE

PROJECT MOVIES

For direct access to project movies please click on the following links: A01A02A03A04, A05A06, A07A10, A11A12A13, A14A15, A16, A18, A19, A20 and A21.

SFB1328

Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling. 

Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown. 

The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.

NEWS

CALL MD STIPENDS

| News

Apply now for the Research Training Group of the SFB1328

In total 8 SCHOLARSHIPS FOR MEDICAL STUDENTS are available

APPLICATIONS UNTIL JUNE 13, 2025…

BOOK

| News

Björn-Philipp Diercks, Project A02, edited the book on "T cell activation"  in the Methods in Molecular Biology series. This book provides detailed,…

SPECIAL ISSUE

| News

ACS Pharmacology & Translational Science is calling for papers for a virtual Special Issue on "Purinergic Signaling".

They are inviting scientists…

April 08, 2025

| JB-Gymnasium

35 Pupils from Johannes-Brahms-Gymnasium together with teachers Mr Wollik and Mrs Wriedt visited 2 lectures in the iMED study program related to…

AWARD

| Jugend_Forscht

On April 4th, 2025 Cumhur Utku Dagli received the 1. Prize of the federal state assessment of ‘Jugend forscht’ for his work entitled “Heat shock and…

SCIENCE SLAM

| science_slam

Prof. Madeleine Bunders, project A19, just participated in a science slam co-organized by European University Alliance for Global Health and the UHH…

For further announcements see:

LATEST PUBLICATION

Müller CE, Bruzzone S, Guse AH. Editorial: Adenine nucleotides in immunity and inflammation. Front Immunol. 2025 Mar 12;16:1585484.

Asada N, Ginsberg P, Paust HJ, Song N, Riedel JH, Turner JE, Peters A, Kaffke A, Engesser J, Wang H, Zhao Y, Khatri R, Gild P, Dahlem R, Diercks BP, Das S, Ignatova Z, Huber TB, Prinz I, Gagliani N, Mittrücker HW, Krebs CF, Panzer U. The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells. Nat Immunol. 2025 Mar 6.

Lorenz H, Menzel S, Roshchyna N, Albrecht B, Gebhardt AJ, Schneider E, Haag F, Rissiek B, Oheim R, Koch-Nolte F, Winzer R, Tolosa E. ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells. Cell Mol Life Sci. 2024 Dec 18;82(1):6. doi: 10.1007/s00018-024-05539-y. 

Gerlach F, Möckl F, Kovacevic D, Brock VJ, Winzer R, Meyer L, Lohr D, Woelk LM, Tolosa E, Werner R, Diercks BP. Imaging Initial Ca2+ Microdomains in Primary T Cells. J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/67075. 

Krukenberg S, Möckl F, Weiß M, Dekiert P, Hofmann M, Gerlach F, Winterberg KJ, Kovacevic D, Khansahib I, Troost B, Hinrichs M, Granato V, Nawrocki M, Hub T, Tsvilovskyy V, Medert R, Woelk LM, Förster F, Li H, Werner R, Altfeld M, Huber S, Clarke OB, Freichel M, Diercks BP, Meier C, Guse AH. MASTER-NAADP: a membrane permeable precursor of the Ca2+mobilizing second messenger NAADP. Nat Commun. 2024 Sep 13;15(1):8008.

von Kalben L, Sauer J, Gee C, Hirnet D, Lohr C. Dopaminergic cAMP signaling in mouse olfactory bulb astrocytes. Neurochem Int. 2024 Oct;179:105828.

 

 

 

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Priv. Doz. Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de

Claudia Voß
Fon: +49  (0) 40 7410 53917
E-Mail: cla.voss©uke.de