INTRODUCTION MOVIE
PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS

PAPER
SFB1328 scientists headed by A14 and Z02 just published in Cellular and Molecular Life Sciences the generation of an ENPP1/CD203a heavy-chain…

SFB1328 Meeting Report: 2nd European Purine Meeting
From September 4 to 6, 2024 the second European Purine Meeting was held in Ferrara, Italy. It was organized by Francesco di Virgilio and Elena…

PAPER
SFB1328 scientists headed by Chris Meier and Andreas Guse just published in Nature Communications the design, synthesis and validation of the first…

SFB1328 Meeting Report: FASEB Science Research Conference ‘NAD Metabolism and Signaling'
The 9th FASEB Science Research Conference ‘NAD Metabolism and Signaling’ took place at Lisbon from August 25 to 29, 2024. Under the auspices of FASEB,…

SFB1328 Meeting Report: GRC on Calcium Signaling
From June 30 to July 5, 2024 the Gordon Research Conference on Calcium Signalling was held in Il Ciocco, Italy. It was organized by Ivan Bogeski and…

THESIS EXCHANGE
Employees on projects A05, A18 and A20 presented their topics in the form of posters at a thesis exchange organized by the biochemistry course at the…
PAPER SCIENCE SIGNALING
Although NAADP was discovered already over 25 years ago, as the most potent Ca2+ mobilizing messenger, the mechanism of action is still unclear. In this SFB publication, we present a long-assumed binding protein for NAADP called Hn1l/Jpt2, which has essential role in activating primary T cells, hence the adaptive immune response.

NEW PRESIDENT OF THE ECS
At the recent general Assembly of the European Calcium Society Prof. Andreas Guse was announced as the new President of the ECS. Furthermore Geert Bultynck is replacing Jan Parys as General Secretary. Congratulations to both!!

OBITUARY
The international scientific community has lost its pioneer in purinergic signalling! Geoffrey Burnstock died on the 2nd of June 2020 at the age of 91 in Melbourne (Australia). Our Collaborative Research Centre SFB1328 on adenine nucleotides in immunity and inflammation is unconceivable without Geoff Burnstock’s seminal work. Several times it has been a privilege to have Geoff Burnstock as plenary speaker during international meetings organised by members of the SFB1328.

RESEARCH TOPIC
Björn Rissiek and Andreas Guse, among others, are organising "The Versatile Role of Nicotinamide Adenine Dinucleotide in Immunity“ as a Research Topic for Frontiers Immunology. Submission deadline for abstracts is 30 June 2020.
For more information see here
5th German Pharm-Tox Summit
At the 5th German Pharm-Tox Summit the annual meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) a whole Symposium was dedicated to the SFB1328.

EVENT
With 90 attendee's and 5 invited Speakers, the "Life after PhD meeting" was a great success!
Special thanks to the PhD students for organising the meeting and to the invited speakers for their open talks and discussions!

For further announcements see:
New Instrumentation
Thanks to the support from the Deutsche Forschungsgesellschaft (DFG) we are eager to go from the formation of Ca2+ microdomains to the analysis of Ca2+ nanodomains with a new Superresolution Spinning-disk microscope!

AWARD
Congratulations to Prof. Dr. med. Friedrich Koch-Nolte und PD Dr. med. Peter Bannas for being awarded with the "Forschungspreis der Hamburger Krebsgesellschaft". The summary of the work is found here (in german).

POSTER PRIZE
Congratulations to Dr. Stephan Menzel and Birte Albrecht (Project Z02) for being awarded with a Poster Prize at the 1st Nanobody Symposium.

SOMMER DES WISSENS
"Wie unsere Zellen ‚twittern‘ – Signalmoleküle bei Immunität und Entzündung" very nice presentation by Dr. Insa Wolf (Projekt A02) at the "Sommer des Wissens" to celebrate 100 years University of Hamburg!

AWARD
Congratulations to Prof. Dr. Christa Müller (Project A11) for being awarded with the "Nauta Award for Medicinial Chemistry and Chemical Biology" by the European Federation of Medicinal Chemistry (EFMC)!

SPECIAL
Congratulations to now PD Dr. René Werner from Project A02 for successfully finishing his Habilation entitled "Non-linear medical image registration and multivariate correspondence modeling on high-dimensional data“!

LATEST PUBLICATION
Lorenz H, Menzel S, Roshchyna N, Albrecht B, Gebhardt AJ, Schneider E, Haag F, Rissiek B, Oheim R, Koch-Nolte F, Winzer R, Tolosa E. ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells. Cell Mol Life Sci. 2024 Dec 18;82(1):6. doi: 10.1007/s00018-024-05539-y.
Gerlach F, Möckl F, Kovacevic D, Brock VJ, Winzer R, Meyer L, Lohr D, Woelk LM, Tolosa E, Werner R, Diercks BP. Imaging Initial Ca2+ Microdomains in Primary T Cells. J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/67075.
Krukenberg S, Möckl F, Weiß M, Dekiert P, Hofmann M, Gerlach F, Winterberg KJ, Kovacevic D, Khansahib I, Troost B, Hinrichs M, Granato V, Nawrocki M, Hub T, Tsvilovskyy V, Medert R, Woelk LM, Förster F, Li H, Werner R, Altfeld M, Huber S, Clarke OB, Freichel M, Diercks BP, Meier C, Guse AH. MASTER-NAADP: a membrane permeable precursor of the Ca2+mobilizing second messenger NAADP. Nat Commun. 2024 Sep 13;15(1):8008.
von Kalben L, Sauer J, Gee C, Hirnet D, Lohr C. Dopaminergic cAMP signaling in mouse olfactory bulb astrocytes. Neurochem Int. 2024 Oct;179:105828.
Koch-Nolte F. Nanobody-based heavy chain antibodies and chimeric antibodies. Immunol Rev. 2024 Aug 30.





