• SFB 1328

    Adenine Nucleotides in Immunity and Inflammation

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB1328 Retreat 2021

    26th - 28th of May 2021

    read more...

Next Science Afternoon

  • 16 Jul
    Science Afternoon 16.07.2025

    2:00–3:00pm Meet the speaker for young scientists in Room SR0.02 and PI meeting online

    3:00–4:00pm Guestspeaker Tongtong Wang –Host Alexander Pfeifer

INTRODUCTION MOVIE

PROJECT MOVIES

For direct access to project movies please click on the following links: A01A02A03A04, A05A06, A07A10, A11A12A13, A14A15, A16, A18, A19, A20 and A21.

SFB1328

Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling. 

Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown. 

The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.

NEWS

AWARD

| Jugend_Forscht

Congratulations to Cumhur Dagli for his 4th prize in the Federal German ‚Jugend forscht‘ contest!

Cumhur Utku Dagli, a young external affiliate of…

Zukunfts-Café

| Science Afternoon

At the “Zukunfts-Café” held on July 02. 2025 at Johannes-Brahms-Gymnasium Prof. Guse (project A01, Z01) presented the research landscape of SFB1328…

Life After PhD & MD Meeting

| News

We would like to invite you all to enjoy this activity with us and get some inspiration from our speakers!

The SFB 1328 decided to create a symposium…

BEST SHORT TALK

| News

Congratulations to Dr. Juan Sierra-Marquez (Project A15) for being awarded the best Short-Talk presentation at the COST Action meeting "Purinergic…

AWARD

| News

Researchers of SFB1328 received Teacher-of-the Year-Awards at the Medical Faculty. These awards are based on student’s evaluation  and appreciate…

June 20, 2025

| MD-Gymnasium

Prof. Andreas Guse (project A01, Z01) visited Marion-Dönhoff-Gymnasium on June 20, 2025 and presented to approx. 120 pupils from senior classes…

For further announcements see:

LATEST PUBLICATION

Woo MS, Brand J, Bal LC, Moritz M, Walkenhorst M, Vieira V, Ipenberg I, Rothammer N, Wang M, Dogan B, Loreth D, Mayer C, Nagel D, Wagner I, Pfeffer LK, Landgraf P, van Ham M, Mattern KM, Winschel I, Frantz N, Sonner JK, Grosshans HK, Miguela A, Bauer S, Meurs N, Müller A, Binkle-Ladisch L, Salinas G, Jänsch L, Dieterich DC, Riedner M, Krüger E, Heppner FL, Glatzel M, Puelles VG, Engler JB, Nyengaard JR, Misgeld T, Kerschensteiner M, Merkler D, Meyer-Schwesinger C, Friese MA. The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Cell. 2025 Jun 13:S0092-8674(25)00616-6

Müller CE, Bruzzone S, Guse AH. Editorial: Adenine nucleotides in immunity and inflammation. Front Immunol. 2025 Mar 12;16:1585484.

Asada N, Ginsberg P, Paust HJ, Song N, Riedel JH, Turner JE, Peters A, Kaffke A, Engesser J, Wang H, Zhao Y, Khatri R, Gild P, Dahlem R, Diercks BP, Das S, Ignatova Z, Huber TB, Prinz I, Gagliani N, Mittrücker HW, Krebs CF, Panzer U. The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells. Nat Immunol. 2025 Mar 6.

Lorenz H, Menzel S, Roshchyna N, Albrecht B, Gebhardt AJ, Schneider E, Haag F, Rissiek B, Oheim R, Koch-Nolte F, Winzer R, Tolosa E. ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells. Cell Mol Life Sci. 2024 Dec 18;82(1):6. doi: 10.1007/s00018-024-05539-y. 

Gerlach F, Möckl F, Kovacevic D, Brock VJ, Winzer R, Meyer L, Lohr D, Woelk LM, Tolosa E, Werner R, Diercks BP. Imaging Initial Ca2+ Microdomains in Primary T Cells. J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/67075. 

 

 

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Priv. Doz. Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de

Claudia Voß
Fon: +49  (0) 40 7410 53917
E-Mail: cla.voss©uke.de