PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
SPECIAL
Congratulations to now PD Dr. Jakob Körbelin from Project A13 for successfully finishing his Habilitation!
PUBLIC OUTREACH
Smell is an often underestimated sense. We often only appreciate it when we lose it. Christian Lohr (Project A07) participated in a video on the…
SFB RETREAT 2025
The #4 Retreat of the 2nd funding period of SFB1328 took place from September 30 to October 2, 2025, at the new research campus II, directly located…
Life After PhD & MD Meeting
#Updated program#
We would like to invite you all to enjoy this activity with us and get some inspiration from our speakers!
The SFB 1328 decided to…
AWARDS
During the 11th ECS Symposium “Crosstalk between Calcium and Adenine Nucleotides", Carolina Pinto (project A07) was awarded the best short talk;…
SYMPOSIUM
The 11th ECS Symposium “Crosstalk between Calcium and Adenine Nucleotides", co-hosted by the SFB1328, which took place in Hamburg from 17th to 19th of…
For further announcements, see LinkedIn
LATEST PUBLICATION
Imai SI, Pirinen E, Sack MN, Treebak JT, Tzoulis C, Bruzzone S, Guse AH, Hottiger MO, Cambronne XA. From Bench to Clinic: The 2024 FASEB Scientific Research Conference on NAD Metabolism and Signaling. Mol Med. 2025 Oct 31;31(1):323.
Kirkgöz K, Sprenger S, Schweigert O, Mohagaonkar S, Walsdorff M, Zeller T, Berisha F, Nikolaev VO, Rybalkin SD. An intracellular recombinant single-chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors. Br J Pharmacol. 2025 Oct 10.
Stamataki M, Lüschow J, Schlumbohm C, Alawi M, Lunding L, Fuchs E, Trepel M, Schwaninger M, Körbelin J. Identification of AAV variants with improved transduction of human vascular endothelial cells by screening AAV capsid libraries in non-human primates. Gene Ther. 2025 Sep 5.
Jaeckstein MY, Miegel L, Behrens J, Stähler T, Diercks BP, Heine M, Koch-Nolte F, Heeren J. The Purinergic Receptor P2X5 Modulates Glucose Metabolism and Expression of Thermogenic Genes in Brown Adipose Tissue. Int J Mol Sci. 2025 Jul 4;26(13):6474.
Woo MS, Brand J, Bal LC, Moritz M, Walkenhorst M, Vieira V, Ipenberg I, Rothammer N, Wang M, Dogan B, Loreth D, Mayer C, Nagel D, Wagner I, Pfeffer LK, Landgraf P, van Ham M, Mattern KM, Winschel I, Frantz N, Sonner JK, Grosshans HK, Miguela A, Bauer S, Meurs N, Müller A, Binkle-Ladisch L, Salinas G, Jänsch L, Dieterich DC, Riedner M, Krüger E, Heppner FL, Glatzel M, Puelles VG, Engler JB, Nyengaard JR, Misgeld T, Kerschensteiner M, Merkler D, Meyer-Schwesinger C, Friese MA. The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Cell. 2025 Jun 13:S0092-8674(25)00616-6
