Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
The first big online retreat of the SFB1328 was successfully accomplished! Many great talks by all the projects and associated projects wanting to integrate into the SFB soon were presented. The number of participants was around 80 and thus lively discussion and remarks were possible.
Guest speakers enriched the atmosphere every evening and gave new insigts into the great field of adenine nucleotides!
For more details see here.
Congratulations to Christa Müller (A11) who has been named editor in chief of ACS Pharmacology & Translational Science. “The journal will set new standards in the field and support diversity, and emerging young scientists will be invited to play an active role,” Müller says.
For further announcements see:
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