SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
Retreat 2021
The first big online retreat of the SFB1328 was successfully accomplished! Many great talks by all the projects and associated projects wanting to integrate into the SFB soon were presented. The number of participants was around 80 and thus lively discussion and remarks were possible.
Guest speakers enriched the atmosphere every evening and gave new insigts into the great field of adenine nucleotides!
For more details see here.
EDITOR IN-CHIEF
Congratulations to Christa Müller (A11) who has been named editor in chief of ACS Pharmacology & Translational Science. “The journal will set new standards in the field and support diversity, and emerging young scientists will be invited to play an active role,” Müller says.
For further announcements see:
LATEST PUBLICATION
Häußler V, Ufer F, Pöttgen J, Wolschke C, Friese MA, Kröger N, Heesen C, Stellmann JP (2021) aHSCT is superior to alemtuzumab in maintaining NEDA and improving cognition in multiple sclerosis. Ann Clin Transl Neurol, online ahead of print
Malsy J, Veletzky L, Heide J, Hennigs A, Gil-Ibanez I, Stein A, Lütgehetmann M, Rosien U, Jasper D, Peine S, Hiller J, Haag F, Schmiedel S, Huber S, Jordan S, Addo MM, Schulze Zur Wiesch J (2021) Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19. Clin Infect Dis, online ahead of print
De Jong KA, Nikolaev VO (2021) Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure. FEBS J, online ahead of print
Hadaeghi F, Diercks BP, Schetelig D, Damicelli F, Wolf IMA, Werner R. Spatio-temporal feature learning with reservoir computing for T-cell segmentation in Ca2+ live-cell fluorescence microscopy. Sci Rep. 2021 Apr 15;11(1):8233.
Roggenkamp HG, Khansahib I, Hernandez C LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH (2021) HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation. Sci Signal 14(675):eabd5647
