2018

2018

Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F. Monitoring the Sensitivity of T Cell Populations Towards NAD(+) Released During Cell Preparation.
Methods Mol Biol. 2018;1813:317-326.

Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell RA, Huber S. Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease.
Crit Rev Immunol. 2018;38(5):415-431.

Menzel S, Adriouch S, Bannas P, Haag F, Koch-Nolte F. Monitoring Expression and Enzyme Activity of Ecto-ARTCs.
Methods Mol Biol. 2018;1813:167-186.

Subramanian H, Froese A, Jönsson P, Schmidt H, Gorelik J, Nikolaev VO. Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP.
Nat Commun. 2018 Jun 22;9(1):2446.

Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell RA, Huber S. Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease. Crit Rev Immunol. 2018;38(5):415-431.

Schetelig D, Sedlacik J, Fiehler J, Frölich A, Knopp T, Sothmann T, Waschkewitz J, Werner R. Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom.
Sci Rep. 2018 Jul 20;8(1):11004.

Zuo H, Han B, Poppinga WJ, Ringnalda L, Kistemaker LEM, Halayko AJ, Gosens R, Nikolaev VO, Schmidt M. Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.
Br J Pharmacol. 2018 Jul;175(14):2988-3006.

Rissiek B, Lukowiak M, Raczkowski F, Magnus T, Mittrücker HW, Koch-Nolte F. In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells.
Front Immunol. 2018 Jul 9;9:1580.

Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OM. I L-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. J Am Soc Nephrol. 2018 Jul;29(7):1825-1837.

Mausberg AK, Szepanowski F, Odoardi F, Flügel A, Kleinschnitz C, Stettner M,Kieseier BC. Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis.
J Neuroinflammation. 2018 Aug 1;15(1):217.

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S,Koch-Nolte F, Eulenburg V, Nicke A. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.
Elife. 2018 Aug 3;7. pii: e36217.

Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samartín A, Pulagam KR, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M. P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis.
EMBO Mol Med. 2018 Aug;10(8). pii: e8743.

Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz OM, Rose-John S, Mittrücker HW. Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells
PLoS One. 2018 Aug 31;13(8):e0203395.

Leutert M, Menzel S, Braren R, Rissiek B, Hopp AK, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO. Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
Cell Rep. 2018 Aug 14;24(7):1916-1929.e5.

Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T. Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.
PLoS One. 2018 Aug 15;13(8):e0201310.

Josts I, Nitsche J, Maric S, Mertens HD, Moulin M, Haertlein M, Prevost S, Svergun DI, Busch S, Forsyth VT, Tidow H. Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs.
Structure. 2018 Aug 7;26(8):1072-1079.e4.

Rosendahl A, Kabiri R, Bode M, Cai A, Klinge S, Ehmke H, Mittrücker HW, Wenzel UO. Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice
Br J Pharmacol. 2018 Sep 30.

Puig B, Brenna S, Magnus T. Molecular Communication of a Dying Neuron in Stroke.
Int J Mol Sci. 2018 Sep 19;19(9). pii: E2834.

Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S, Arumugam TV, Magnus T, Huber S, Gelderblom M, Drummond GR, Sobey CG, Kim HA. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
JCI Insight. 2018 Sep 20;3(18). pii: 121560.

Josts I, Niebling S, Gao Y, Levantino M, Tidow H, Monteiro D. Photocage-initiated time-resolved solution X-ray scattering investigation of protein dimerization.
IUCrJ. 2018 Sep 13;5(Pt 6):667-672.

Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M,Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T. Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.
Cell Rep. 2018 Sep 11;24(11):2946-2956.

Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, Hammerschmidt P, Loureiro R, Kiefer C, Hansmeier NR, Khani S, Bergami M, Heine M, Ntini E, Frommolt P, Zentis P, Ørom UA, Heeren J, Blüher M, Bilban M, Kornfeld JW. LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.
Nat Commun. 2018 Sep 6;9(1):3622.

Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T. Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.
Cell Rep. 2018 Sep 11;24(11):2946-2956.

Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G. Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
Nat Microbiol. 2018 Oct;3(10):1161-1174.

Wiegert JS, Pulin M, Gee CE, Oertner TG. The fate of hippocampal synapses depends on the sequence of plasticity-inducing events.
Elife. 2018 Oct 12;7. pii: e39151.

Schetelig D, Frölich A, Knopp T, Werner R. A new cerebral vessel benchmark dataset (CAPUT) for validation of image-based aneurysm deformation estimation algorithms.
Sci Rep. 2018 Oct 30;8(1):15999

Beck S, Yu-Strzelczyk J, Pauls D, Constantin OM, Gee CE, Ehmann N, Kittel RJ, Nagel G, Gao S. Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.
Front Neurosci. 2018 Oct 2;12:643.

Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J. The adaptor protein PID1 regulates receptor-dependentendocytosis of postprandial triglyceride-rich lipoproteins.
Mol Metab. 2018 Oct;16:88-99.

Moeyaert B, Holt G, Madangopal R, Perez-Alvarez A, Fearey BC, Trojanowski NF, Ledderose J, Zolnik TA, Das A, Patel D, Brown TA, Sachdev RNS, Eickholt BJ, Larkum ME, Turrigiano GG, Dana H, Gee CE, Oertner TG, Hope BT, Schreiter ER. Improved methods for marking active neuron populations.
Nat Commun. 2018 Oct 25;9(1):4440.

Wolters-Eisfeld G, Mercanoglu B, Hofmann BT, Wolpers T, Schnabel C, Harder S, Steffen P, Bachmann K, Steglich B, Schrader J, Gagliani N, Schlüter H, Güngör C, Izbicki JR, Wagener C, Bockhorn M. Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice.
Exp Mol Med. 2018 Oct 10;50(10):133.

Ziegler MC, Grañana FB, Garcia-Beltran WF, Schulze Zur Wiesch J, Hoffmann C,Rechtien A, Lunemann S, Altfeld M. Stable Frequencies of HLA-C(*)03:04/Peptide-Binding KIR2DL2/3(+) Natural Killer Cells Following Vaccination.
Front Immunol. 2018 Oct 17;9:2361.

Schuster S, Braass H, Iking-Konert C, Schnoor U, Matschke J, Gerloff C, Thomalla G, Magnus T. Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes.
Neurol Clin Pract. 2018 Oct;8(5):451-455.

Adesso S, Paterniti I, Cuzzocrea S, Fujioka M, Autore G, Magnus T, Pinto A, Marzocco S. AST-120 Reduces Neuroinflammation Induced by Indoxyl Sulfate in Glial Cells.
J Clin Med. 2018 Oct 17;7(10). pii: E365.

Ziegler MC, Grañana FB, Garcia-Beltran WF, Schulze Zur Wiesch J, Hoffmann C,Rechtien A, Lunemann S, Altfeld M. Stable Frequencies of HLA-C(*)03:04/Peptide-Binding KIR2DL2/3(+) Natural Killer Cells Following Vaccination.
Front Immunol. 2018 Oct 17;9:2361.

Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S, Arumugam TV, Magnus T, Huber S, Gelderblom M, Drummond GR, Sobey CG, Kim HA. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke. JCI Insight. 2018 Sep 20;3(18). pii: 121560.

Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.
Sci Rep. 2018 Nov 13;8(1):16775.

Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F. CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.
Front Immunol. 2018 Nov 19;9:2553.

Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert AE, Hess LU, Poch T, Martrus G, Garcia-Beltran WF, Körner C, Ziegler AE, Richert L, Oldhafer KJ, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M. Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture.
Gastroenterology. 2018 Nov;155(5):1366-1371.e3.

Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T.HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Front Immunol. 2018 Nov 13;9:2611.

Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T.HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Front Immunol. 2018 Nov 13;9:2611.

Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL. Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.
Sci Rep. 2018 Nov 13;8(1):16775.

Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms.
JCI Insight. 2018 Nov 2;3(21). pii: 99470.

Müller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Löwe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschüren C, Töller M, Vettorazzi E, Wegscheider K. Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey
Exp Clin Endocrinol Diabetes. 2018 Nov 26.

Bannas P, Koch-Nolte F. Perspectives for the Development of CD38-Specific Heavy Chain Antibodies as Therapeutics for Multiple Myeloma.
Front Immunol. 2018 Nov 6;9:2559.

Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F. CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.
Front Immunol. 2018 Nov 19;9:2553.

Ruthenbeck A, Marangoni E, Diercks BP, Krüger A, Froese A, Bork NI, Nikolaev VO, Guse AH, Meier C. Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays.
Molecules. 2018 Nov 13;23(11). pii: E2960.

Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH. NAD binding by human CD38 analyzed by Trp189 fluorescence.
Biochim Biophys Acta Mol Cell Res. 2018 Nov 22. pii: S0167-4889(18)30508-1.

Nitsche J, Josts I, Heidemann J, Mertens HD, Maric S, Moulin M, Haertlein M, Busch S, Forsyth VT, Svergun DI, Uetrecht C, Tidow H. Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin.
Commun Biol. 2018 Nov 26;1:206.

Sorini C, Cardoso RF, Gagliani N, Villablanca EJ. Commensal Bacteria-Specific CD4(+) T Cell Responses in Health and Disease.
Front Immunol. 2018 Nov 20;9:2667.

Creon A, Josts I, Niebling S, Huse N, Tidow H. Conformation-specific detection of calmodulin binding using the unnatural amino acid p-azido-phenylalanine (AzF) as an IR-sensor. Struct Dyn. 2018 Nov 7;5(6):064701.

Fliegert R, Hölzer HT, Guse AH. TRPM2 activation: Paradigm shifted?
Cell Calcium. 2018 Dec;76:132-134.

Brehm TT, Schulze Zur Wiesch J, Lütgehetmann M, Tappe D, Eisermann P, Lohse AW, Addo MM, Schmiedel S. Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.
Infection. 2018 Dec;46(6):847-853.

Jimenez-Mateos EM, Smith J, Nicke A, Engel T. Regulation of P2X7 receptor expression and function in the brain.
Brain Res Bull. 2018 Dec 26. pii: S0361-9230(18)30734

Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW. T (RM) maintenance is regulated by tissue damage via P2RX7.
Sci Immunol. 2018 Dec 14;3(30). pii: eaau1022.

Calcinotto A, Brevi A, Chesi M, Ferrarese R, Garcia Perez L, Grioni M, Kumar S, Garbitt VM, Sharik ME, Henderson KJ, Tonon G, Tomura M, Miwa Y, Esplugues E,Flavell RA, Huber S, Canducci F, Rajkumar VS, Bergsagel PL, Bellone M. Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression. Nat Commun. 2018 Dec 3;9(1):4832.

Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH. ORAI1, STIM1/2, and RYR1 shape subsecond Ca(2+) microdomains upon T cell activation.
Sci Signal. 2018 Dec 18;11(561). pii: eaat0358.

Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber FJ, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell RA, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S. Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3(+) Regulatory T Cells.
J Immunol. 2018 Dec 15;201(12):3558-3568

Gattkowski E, Johnsen A, Bauche A, Möckl F, Kulow F, Garcia Alai M, Rutherford TJ, Fliegert R, Tidow H. Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.
Biochim Biophys Acta Mol Cell Res. 2018 Dec 22. pii: S0167-4889(18)30540-8.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S. Molecular and functional heterogeneity of IL-10-producing CD4(+) T cells
Nat Commun. 2018 Dec 21;9(1):5457.

Roncarolo MG, Gregori S, Bacchetta R, Battaglia M, Gagliani N. The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.
Immunity. 2018 Dec 18;49(6):1004-1019.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S. Molecular and functional heterogeneity of IL-10-producing CD4(+) T cells. Nat Commun. 2018 Dec 21;9(1):5457.

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de