2019

2019

Jank L, Pinto-Espinoza C, Duan Y, Koch-Nolte F, Magnus T, Rissiek B (2019) Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy. Antibodies (Basel) 8:5

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH (2019) Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation. Biochem Soc Trans47:329-337

Zeiner J, Loukovaara S, Losenkova K, Zuccarini M, Korhonen AM, Lehti K, Kauppinen A, Kaarniranta K, Müller CE, Jalkanen S, Yegutkin GG (2019) Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage. J Mol Med (Berl) 97:341-354

Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA (2019) Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem62:3677-3695

Linden J, Koch-Nolte F, Dahl G (2019) Purine Release, Metabolism, and Signaling in the Inflammatory Response. Annu Rev Immunol 37:325-347

Vaz PK, Hartley CA, Lee SY, Sansom FM, Adams TE, Stalder K, Pearce L, Lovrecz G, Browning GF, Müller CE, Devlin JM (2019) Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses. J Virol 93:e01404-18

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL (2019) Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2. J Org Chem 84:6143-6157

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F (2019) P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP. Purinergic Signal 15:155-166

Martínez-García JJ, Martínez-Banaclocha H, Angosto-Bazarra D, de Torre-Minguela C, Baroja-Mazo A, Alarcón-Vila C, Martínez-Alarcón L, Amores-Iniesta J, Martín-Sánchez F, Ercole GA, Martínez CM, González-Lisorge A, Fernández-Pacheco J, Martínez-Gil P, Adriouch S, Koch-Nolte F, Luján J, Acosta-Villegas F, Parrilla P, García-Palenciano C, Pelegrin P (2019) P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. Nat Commun 10:2711

Beiersdorfer A, Scheller A, Kirchhoff F, Lohr C (2019) Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca2+ transients and neurovascular coupling. Glia67:1385-1400

Gattkowski E, Johnsen A, Bauche A, Möckl F, Kulow F, Garcia Alai M, Rutherford TJ, Fliegert R, Tidow H (2019) Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2. Biochim Biophys Acta Mol Cell Res 1866:1162-1170

Schneider E, Rissiek A, Winzer R, Puig B, Rissiek B, Haag F, Mittrücker HW, Magnus T, Tolosa E (2019) Generation and Function of Non-cell-bound CD73 in Inflammation. Front Immunol 10:1729

Wittner M, Schlicker V, Libera J, Bockmann JH, Horvatits T, Seiz O, Kummer S, Manthey CF, Hüfner A, Kantowski M, Rösch T, Degen O, Huber S, Eberhard JM, Schulze Zur Wiesch J (2019) Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis. PLoS One14:e0220008

Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH (2019) NAD binding by human CD38 analyzed by Trp189 fluorescence. Biochim Biophys Acta Mol Cell Res 1866:1189-1196

Koch-Nolte F, Eichhoff A, Pinto-Espinoza C, Schwarz N, Schäfer T, Menzel S, Haag F, Demeules M, Gondé H, Adriouch S (2019) Novel biologics targeting the P2X7 ion channel. Curr Opin Pharmacol 47:110-118

Kopp R, Krautloher A, Ramírez-Fernández A, Nicke A (2019) P2X7 Interactions and Signaling - Making Head or Tail of It. Front Mol Neurosci 12:183

Eichhoff AM, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F (2019) Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors. Mol Ther Methods Clin Dev 15:211-220

Jimenez-Mateos EM, Smith J, Nicke A, Engel T (2019) Regulation of P2X7 receptor expression and function in the brain. Brain Res Bull 151:153-163

Mundt S, Greter M, Flügel A, Becher B (2019) The CNS Immune Landscape from the Viewpoint of a T Cell. Trends Neurosci 42:667-679

Bergmann P, Garcia de Paco E, Rissiek B, Menzel S, Dubberke G, Hua J, Rassendren F, Ulmann L, Koch-Nolte F (2019) Generation and Characterization of Specific Monoclonal Antibodies and Nanobodies Directed Against the ATP-Gated Channel P2X4. Front Cell Neurosci 13:498

Nassir M, Mirza S, Arad U, Lee S, Rafehi M, Yaw Attah I, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B (2019) Adenine-(methoxy)-ethoxy-Pα,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes. Org Biomol Chem 17:9913-9923

Diercks BP, Werner R, Schetelig D, Wolf IMA, Guse AH (2019) High-Resolution Calcium Imaging Method for Local Calcium Signaling. Methods Mol Biol 1929:27-39

Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A (2019) β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration. Nature 566:503-508

Parys JB, Guse AH (2019) Full focus on calcium. Sci Signal 12(599):eaaz0961

Li D, Zavaglia M, Wang G, Xie H, Hu Y, Werner R, Guan JS, Hilgetag CC (2019) Discrimination of the hierarchical structure of cortical layers in 2-photon microscopy data by combined unsupervised and supervised machine learning. Sci Rep 9:7424

Bedke T, Muscate F, Soukou S, Gagliani N, Huber S (2019) IL-10-producing T cells and their dual functions. Semin Immunol 44:101335

Huchting J, Vanderlinden E, Van Berwaer R, Meier C, Naesens L (2019) Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res 167:1-5

Tramontano E, Tarbet B, Spengler JR, Seley-Radtke K, Meier C, Jordan R, Janeba Z, Gowen B, Gentry B, Esté JA, Bray M, Andrei G, Schang LM; International Society for Antiviral Research (2019) Meeting report: 32nd International Conference on Antiviral Research. Antiviral Res 169:104550

Harberts J, Zierold R, Fendler C, Koitmäe A, Bayat P, Fernandez-Cuesta I, Loers G, Diercks BP, Fliegert R, Guse AH, Ronning C, Otnes G, Borgström M, Blick RH (2019) Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology. RSC Advances 20

Dikolayev V, Tuganbekov T, Nikolaev VO (2019) Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis. Front Physiol 10:1406

Beiersdorfer A, Lohr C (2019) AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells. Front Cell Neurosci 13:451

Rotermund N, Schulz K, Hirnet D, Lohr C (2019) Purinergic Signaling in the Vertebrate Olfactory System. Front Cell Neurosci 13:112

Scheja L, Heeren J (2019) The endocrine function of adipose tissues in health and cardiometabolic disease. Nat Rev Endocrinol 15:507-524

Nassir M, Arad U, Lee SY, Journo S, Mirza S, Renn C, Zimmermann H, Pelletier J, Sévigny J, Müller CE, Fischer B (2019) Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes. Purinergic Signal 15:247-263

Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA (2019) Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem62:3677-3695

Karimzadeh H, Kiraithe MM, Oberhardt V, Salimi Alizei E, Bockmann J, Schulze Zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C (2019) Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8 + T Cells and Evolve at the Population Level. Gastroenterology156:1820-1833

Eichhoff AM, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F (2019) Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors. Mol Ther Methods Clin Dev 15:211-220

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de