2024
- The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
- The eATP/P2×7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation
- SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor
- TRPC3/6 Channels Mediate Mechanical Pain Hypersensitivity via Enhancement of Nociceptor Excitability and of Spinal Synaptic Transmission
- Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 M<sup>pro</sup> Inhibitors With Robust Potency and Drug-like Profile
- Stroke of Consistency: Streamlining Multicenter Protocols for Enhanced Reproducibility of Infarct Volumes in Preclinical Stroke Research
- Bidirectional Effect of Long-Term Δ<sup>9</sup>-Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome
- Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
- Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
- Enhanced browning of adipose tissue by mirabegron-microspheres
- MASTER-NAADP: a membrane permeable precursor of the Ca<sup>2+</sup> mobilizing second messenger NAADP
- The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle
- Median nerve lesions in pediatric displaced supracondylar humerus fracture: A prospective neurological, electrodiagnostic and ultrasound characterization
- A molecular mechanism to diversify Ca<sup>2+</sup> signaling downstream of Gs protein-coupled receptors
- Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice
- Nanobody-based heavy chain antibodies and chimeric antibodies
- Live Cell Monitoring of Phosphodiesterase Inhibition by Sulfonylurea Drugs
- Expansion of human γδ T cells in periphery: Lessons learned from development, infections, and compromised thymic function
- Neuroserpin and Extracellular Vesicles in Ischemic Stroke: Partners in Neuroprotection?
- Impact of breathing signal-guided dose modulation on step-and-shoot 4D CT image reconstruction
- Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection
- Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy
- Ca<sup>2+</sup> puffs underlie adhesion-triggered Ca<sup>2+</sup> microdomains in T cells
- Community-Acquired Bacterial Meningoencephalitis: The New Guideline
- Efficacy and safety of palliative treatment in patients with autoimmune liver disease-associated hepatocellular carcinoma
- The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
- Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity
- Dopaminergic cAMP signaling in mouse olfactory bulb astrocytes
- The many facets of TMEM63/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond
- Non-canonical function of ADAM10 in presynaptic plasticity
- Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy
- Slack K+ channels confer protection against myocardial ischemia/reperfusion injury
- Changes in Neuroimmunological Synapses During Cerebral Ischemia
- An efficient AAV vector system of Rec2 serotype for intravenous injection to study metabolism in brown adipocytes in vivo
- The Impact of Hearing Aids on Listening Effort and Listening-Related Fatigue - Investigations in a Virtual Realistic Listening Environment
- B cells expressing mutated IGHV1-69-encoded antigen receptors related to virus neutralization show lymphoma-like transcriptomes in patients with chronic HCV infection
- Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system
- Microglia targeting by adeno-associated viral vectors
- Stability analysis of patient-specific 4DCT- and 4DCBCT-based correspondence models
- Gene therapy targeting the blood-brain barrier
- Corrigendum to "SARS-CoV-2 M<sup>pro</sup> oligomerization as a potential target for therapy" [Int. J. Biol. Macromol. 267 (Part 1) (May 2024) 131392]
- Inefficient tissue immune response against MPXV in an immunocompromised mpox patient
- Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
- Exploring cell death mechanisms in spheroid cultures using a novel application of the RIP3-caspase3-assay
- Tepotinib in a Patient With Advanced Non-Small Cell Lung Cancer Harboring MET Exon 14 Skipping Undergoing Concomitant Hemodialysis for Renal Failure: A Case Report
- Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
- Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension
- Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis: a retrospective analysis
- Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction
- High levels of soluble CD73 unveil resistance to BRAF inhibitors in melanoma cells
- Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
- Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease
- Ferroptosis in health and disease
- Intergenic risk variant rs56258221 skews the fate of naive CD4<sup>+</sup> T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
- Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
- Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity
- STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
- Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
- Proof of infectivity of hepatitis E virus particles from the ejaculate of chronically infected patients
- Protective function of sclerosing cholangitis on IBD
- Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
- Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire
- Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis
- Analytical and clinical validation of a novel, laboratory-developed, modular multiplex-PCR panel for fully automated high-throughput detection of 16 respiratory viruses
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study
- Pro- and antitumorigenic functions of γδ T cells
- Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics
- Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
- Immunity against measles, mumps, rubella, and varicella among homeless individuals in Germany - A nationwide multi-center cross-sectional study
- The neuropathobiology of multiple sclerosis
- Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation
- Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
- From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists
- Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
- Unlocking the paracrine crosstalk: adipocyte-derived factors affect carbonic anhydrase IX expression in colon and breast cancer cells
- Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A<sub>2A</sub> Receptor
- Streamlined Generation of CRISPR/Cas9-Mediated Single-Cell Knockout Clones in Murine Cell Lines
- Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs
- The role of compartmentalized β-AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes
- Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
- Sulfonylureas exert antidiabetic action on adipocytes by inhibition of PPARγ serine 273 phosphorylation
- Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases
- Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact
- Bulevirtide monotherapy in patients with chronic HDV: Efficacy and safety results through week 96 from a phase III randomized trial
- Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
- New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
- Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
- The Joint Vasculitis Registry in German-speaking countries (GeVas): subgroup analysis of 195 GCA patients
- Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead
- Correction to "Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity"
- Empowering Voices: Inspiring Women in Medicinal Chemistry
- Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling
- NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells
- The Joint Vasculitis Registry in German-speaking countries (GeVas): subgroup analysis of 266 AAV patients
- AKAP12 Overexpression Affects Cardiac Function via PDE8
- Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins
- Generation and characterization of antagonistic anti-human CD39 nanobodies
- Clinical Presentation and Outcome of Critically Ill Patients with Inflammatory Bowel Disease
- Treatment of Cerebral Histiocytosis With Low Dose of Cobimetinib: A Report of 2 Cases