A04

A04

This project aims at the further development and the extension of chemical routes for the synthesis of lipophilic, bioreversibly modified and/or photo-caged derivatives of the highly polar second messengers nicotinic acid adenine dinucleotide phosphate (MASTER-NAADP), (2’-deoxy)adenosine diphosphate-5-ribose ((2d)ADPR) and cyclic nucleoside monophosphates (cNMPs). Furthermore, bioinspired membrane-linked, fluorescent and ATP-selective chemosensors for the determination of ATP concentrations at cell surfaces will be developed. Thus, this project will address the central demand of the intracellular delivery and the detection of polyphosphorylated adenosine metabolites.

Prof. Dr. Chris Meier

Selected publications

 

1. Zhao C, Weber S, Schols D, Balzarini J, Meier C (2020) Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase. Angew Chem Int Ed Engl 59:22063-22071
2. Jia X, Schols D, Meier C (2020) Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues. J Med Chem 63:6991-7007.
3. Jia X, Schols D, Meier C (2020) Anti-HIV-active Nucleoside Triphosphate Prodrugs. J Med Chem 63:6003-27.
4. Fehling H*, Choy SL*, Ting F*, Landschulze D, Bernin H, Lender SC, Mühlenpfordt M, Bifeld E, Eick J, Marggraff C, Kottmayr N, Groneberg M, Hoenow S, Sellau J, Clos J, Meier C, Lotter H  (2020) Antileishmanial Effects of Synthetic EhPIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan. Antimicrob Agents Chemother 64:e00161-20. 
5. Shannon A, Selisko B, Le NT, Huchting J, Touret F, Piorkowski G, Fattorini V, Ferron F, Decroly E, Meier C, Coutard B, Peersen O, Canard B (2020) Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis. Nature Commun 11:4682.
6. Huchting J, Vanderlinden E, Winkler M, Nasser H, Naesens L, Meier C (2018) Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and its De-Fluoro-Analogue T-1105 as Potent Influenza Virus Inhibitors. J Med Chem 61:6193-210.
7. Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH (2018) ORAI1, STIM1/2, and RYR1 shape subsecond Ca²⁺ microdomains upon T cell activation. Sci Signal 18;11(561).
8. Gollnest T, Dinis de Oliveira T, Rath A, Hauber I, Schols D, Balzarini J, Meier C (2016) Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues. Angew Chem Int Ed 55:5255-5258.
9. Gollnest T, Dinis de Oliveira T, Schols D, Balzarini J, Meier C (2015) The TriPPPro-Approach: Lipophilic Prodrugs of Nucleoside Triphosphates as Biochemical Probes and Potential Antivirals. Nat Commun 6:8716
10. Weinschenk L, Schols D, Balzarini J, Meier C (2015) Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides. J Med Chem 58:6114-6130.

 

 

 

 

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