SFB 2025
- Anatomy-informed deep learning and radiomics for neurofibroma segmentation in whole-body MRI
- Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs
- Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC
- Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors
- Low Synovial Lymphocyte Percentage as a Novel Diagnostic Marker of Periprosthetic Joint Infection
- From Bench to Clinic: The 2024 FASEB Scientific Research Conference on NAD Metabolism and Signaling
- Discovery and characterization of quinoxaline and quinoline carboxamides as allosteric cannabinoid receptor modulators
- Fast enrichment and detection of circulating tumor cells from large volumes of whole blood of breast cancer patients utilizing a functionalized bioaffinity CTC filtration membrane
- Five-Year German PrEP cohort reveals high HIV protection and persistent STI burden: implications for individualized and flexible prevention strategies
- Physiological functions and pharmacological targeting of transient receptor potential channels
- Genetic Deletion of the Purinergic Receptor <em>P2rx7</em> Worsens the Phenotype of α‑Sarcoglycan Muscular Dystrophy
- Serum IL-6 is a prognostic biomarker for advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab
- Activated CaMKIIδ translocates to the RyR nanodomain in cardiomyocytes
- An intracellular recombinant single-chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors
- Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment
- TRPV6 channel function is involved in endometrial epithelial cell Ca<sup>2+</sup> signaling and female mouse fecundity
- HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration
- Defective proviruses cause T cell reprogramming through promoter exaptation in HIV-1 infection
- Crosstalk between the microbiota and intestinal dendritic cells in IBD
- A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD
- LMP7 as a Target for Coronavirus Therapy: Inhibition by Ixazomib and Interaction with SARS-CoV-2 Proteins Nsp13 and Nsp16
- Author Correction: Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis
- Dose Reduction in 4-Dimensional Computed Tomography Imaging: Breathing Signal-Guided Deep Learning-Driven Data Acquisition
- TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke
- The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity
- Prevalence and risk factors of viral hepatitis and HIV among people experiencing homelessness in Germany based on a nationwide study
- New biosensors and transgenic mice for multiplex cGMP imaging
- Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons
- A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
- Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure
- Subtype-specific structural features of the hearing loss-associated human P2X2 receptor
- Preclinical Ischemic Stroke Multicenter (PRISM) Trials Collective Statement: Opportunities, Challenges, and Recommendations for a New Era
- Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity
- Kikuchi-Fujimoto disease: case report of a 32-year-old woman with lymphadenopathy and fever
- Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue
- Correction: Identification of AAV variants with improved transduction of human vascular endothelial cells by screening AAV capsid libraries in non-human primates
- Sex hormones regulate the sexual dimorphism of the lung resident immune milieu
- A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients
- Photoreceptor activation drives the expression of the immediate-early gene Egr1 in inner retinal neurons
- Ultrastructural analysis of synapses after induction of spike-timing-dependent plasticity
- Most prominent challenges in translational neuroscience and strategic solutions to bridge the gaps: Perspectives from an editorial board interrogation
- Supplementary motor area microstructure defines the extent of gait impairment in Parkinson's disease
- Identification of AAV variants with improved transduction of human vascular endothelial cells by screening AAV capsid libraries in non-human primates
- TRPC4 regulates limbic behavior and neuronal development by stabilizing dendrite branches through actomyosin-driven integrin activation
- Research gaps for children who are HIV-exposed but uninfected: outcomes of a research prioritisation workshop
- HLA-A∗03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysis
- A bottom-up approach to find lead compounds in expansive chemical spaces
- 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
- Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice
- Corrigendum to "Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice" [Brain Behav. Immun. 120 (2024) 121-140]
- HIV-1 infection of macrophages differentially primes NK-cell cytotoxicity and proinflammatory cytokine production
- Pathology-oriented multiplexing enables integrative disease mapping
- TRPML2 channel modulation by PI(3,5)P₂ and small-molecule agonists controls endosomal vesicle dynamics
- Pregnancy-acquired memory CD4<sup>+</sup> regulatory T cells improve pregnancy outcome in mice
- Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis
- The Purinergic Receptor P2X5 Modulates Glucose Metabolism and Expression of Thermogenic Genes in Brown Adipose Tissue
- Neurofilament Light Chain in Serum and CSF as a Potential Biomarker for Primary Angiitis of the Central Nervous System
- Treatment of neuroimmunological diseases with chimeric antigen receptor (CAR) T cells : Experience and new developments
- Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation Disease
- Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants
- Long-Term Real-World Use of Cabotegravir/Rilpivirine: Adherence and Virological Efficacy over a 44-Month Observation Period
- Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak
- Expansion of CD103<sup>+</sup>CD69<sup>+</sup>CD8<sup>+</sup> cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia
- Reduction of neuronal activity mediated by blood-vessel regression in the adult brain
- Cluster-based human-in-the-loop strategy for improving machine learning-based circulating tumor cell detection in liquid biopsy
- Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
- Synthesis, Labeling, and Biological Evaluation of P2Y<sub>12</sub> Receptor Radioligands for Positron Emission Tomography Imaging of Neuroinflammation
- Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System-A Multicenter Cohort Study in 163 Patients
- GPR17 - orphan G protein-coupled receptor with therapeutic potential
- Recanalization and reperfusion in clinically-relevant porcine model of stroke
- The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
- TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family
- Biopsy-proven PACNS: results from the large, multicentre cohort of cerebral vasculitis patients
- Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca<sup>2+</sup> import and H<sup>+</sup> efflux
- Adaptation and validation of a gastrointestinal panel to detect diarrheal virus pathogens on a high-throughput qPCR system
- The transcriptional landscape of atrial fibrillation: A systematic review and meta-analysis
- Arteries are finely tuned thermosensors regulating myogenic tone and blood flow
- Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice
- Age and sex-specific differences of the intrafemoral and intratibial morphology using the Citak classification in patients undergoing total knee arthroplasty
- Effects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity
- Non-alcoholic fatty liver disease, in contrast to alcoholic liver disease, is associated with lower socio-economic status: results from a German referral center
- Acyclic purine and pyrimidine nucleotide analogs as ecto-5'-nucleotidase (CD73) inhibitors
- Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5'-Monophosphate
- Species Differences of P2X4 Receptor Modulators
- Selective, Non-nucleotidic Radiotracer for P2Y<sub>12</sub> Receptors: Design, Synthesis, Characterization, and Imaging of Brain Slices
- Design, development and evaluation of a tritium-labeled radiotracer for ecto-5'-nucleotidase (CD73) - A versatile research tool and diagnostic agent for personalized medicine
- Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
- Sla2 is a core interaction hub for clathrin light chain and the Pan1/End3/Sla1 complex
- Altered CD4 T cell response in oligometatastic non-small cell lung cancer brain metastasis
- Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches
- Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver
- Altered mitochondrial mass and fatty acid uptake by natural killer cells in HIV-exposed uninfected children at 6 years of age
- Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis
- ChiraKit: an online tool for the analysis of circular dichroism spectroscopy data
- Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease
- Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells
- Acral necrosis in a 62-year-old female after travelling to Equatorial Guinea
- Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2
- Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases
- Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models