Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
5th German Pharm-Tox Summit
At the 5th German Pharm-Tox Summit the annual meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) a whole Symposium was dedicated to the SFB1328.
For further announcements see:
Perez-Alvarez A, Fearey BC, O'Toole RJ, Yang W, Arganda-Carreras I, Lamothe-Molina PJ, Moeyaert B, Mohr MA, Panzera LC, Schulze C, Schreiter ER, Wiegert JS, Gee CE, Hoppa MB, Oertner TG. Freeze-frame imaging of synaptic activity using SynTagMA. Nat Commun. 2020 May 18;11(1):2464.
Eberhard JM, Angin M, Passaes C, Salgado M, Monceaux V, Knops E, Kobbe G, Jensen B, Christopeit M, Kröger N, Vandekerckhove L, Badiola J, Bandera A, Raj K, van Lunzen J, Hütter G, Kuball JHE, Martinez-Laperche C, Balsalobre P, Kwon M, Díez-Martín JL, Nijhuis M, Wensing A, Martinez-Picado J, Schulze Zur Wiesch J, Sáez-Cirión A. Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1. Sci Transl Med. 2020 May 6;12(542):eaay9355.
Rissiek B, Stabernack J, Cordes M, Duan Y, Behr S, Menzel S, Magnus T, Koch-Nolte F. Astrocytes and Microglia Are Resistant to NAD(+)-Mediated Cell Death Along the ARTC2/P2X7 Axis. Front Mol Neurosci. 2020 Jan 14;12:330.
Baszczyňski, O., Watt, J.M., Rozewitz, M.D., Fliegert R, Guse AH, and Potter BVL. (2020) Synthesis of phosphonoacetate analogues of the second messenger adenosine 5ʹ-diphosphate ribose (ADPR). RSC Advances. 2020,10, 1776-1785.
Huang, Y., Fliegert, R., Guse, A.H., Lü, W., and Du J. (2020) A structural overview of the ion channels of the TRPM family. Cell Calcium. 85:102111.