• SFB 1328

    Adenine Nucleotides in Immunity and Inflammation

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB Retreat 2022 Timmendorfer Strand

  • SFB1328 Retreat 2021

    26th - 28th of May 2021

    read more...

Next Science Afternoon

  • 12 Jun
    Science Afternoon 12.06.2024

    2.00 - 3.00pm meet the speaker for young Scientist N30 & PI meeting online


    3.00 - 3.45pm Guestspeaker

    Prof. Dr. Barbara M. Braunger

    UKE –…

INTRODUCTION MOVIE

PROJECT MOVIES

For direct access to project movies please click on the following links: A01A02A03A04, A05A06, A07A10, A11A12A13, A14 and A15.

SFB1328

Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling. 

Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown. 

The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.

PUBLIC OUTREACH

A great attendance from the SFB1328 at the GRC on Calcium Signaling in Italy.

 

RESEARCH TOPIC

Very successful Frontiers Research Topic on "Adenine Nucleotides in Immunity and Inflammation"!! For further information and publications see Frontiers Research Topic.

AWARD

Congratulations to Dr. Riekje Winzer (Project A14) for being awarded the "Heinrich Netheler-Promotionspreis für Molekularbiologie" by the Freundes- und Förderkreis des UKE! 

For further announcements see:

LATEST PUBLICATION

Sierra-Marquez J, Schaller L, Sassenbach L, Ramírez-Fernández A, Alt P, Rissiek B, Zimmer B, Schredelseker J, Hector J, Stähler T, Koch-Nolte F, Staab-Weijnitz CA, Dietrich A, Kopp R, Nicke A. Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction. Front Immunol. 2024 Jun 17;15:1425938.

Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024 Jun 7:S0092-8674(24)00576-2. 

Eden T, Schaffrath AZ, Wesolowski J, Stähler T, Tode N, Richter N, Schäfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall CM, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt AJ, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor CG, Hartlepp KF, Schleer H, Füner J, Tomas NM, Haag F, Rissiek B, Mann AM, Menzel S, Koch-Nolte F. Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire. Nat Commun. 2024 Jun 3;15(1):4728.

Wittek A, Steglich B, Casar C, Seiz O, Huber P, Ehlken H, Reher D, Wende S, Bedke T, Kempski J, Böttcher M, Bang C, Thingholm L, Krech T, Lohse AW, Sauter G, Rösch T, Franke A, Schramm C, Gagliani N, Pelczar P, Huber S. A Gradient of Intestinal Inflammation in Primary Sclerosing Cholangitis. Inflamm Bowel Dis. 2024 Jun 3;30(6):900-910.

Diercks BP. The importance of Ca2+ microdomains for the adaptive immune response. Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119710.

 

Contact

University Medical Center Hamburg-Eppendorf 
Department of Biochemistry and Molecular Cell Biology 
Martinistrasse 52
20246 Hamburg

Scientific Coordinator

Dr. Björn-Philipp Diercks
Fon: +49  (0) 40 7410 54338
E-Mail: b.diercks©uke.de

Administration

Laura Mitsching
Fon: +49  (0) 40 7410 50301
E-Mail: l.mitsching©uke.de