SFB1328
PROJECT MOVIES
For direct access to project movies please click on the following links: A01, A02, A03, A04, A05, A06, A07, A10, A11, A12, A13, A14, A15, A16, A18, A19, A20 and A21.
SFB1328
Extracellular and intracellular adenine nucleotides (AN) impact on all central processes in biology and medicine. AN are essential and ubiquitous signaling molecules involved in regulating universal cellular processes, including (i) cell-cell communication and (ii) intracellular signaling.
Unresolved issues regarding the signaling function of extracellular AN in inflammation, e.g. adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD), relate to the timing and location of their release, their conversion by ecto-enzymes, and their biological role within the balance of inflammatory processes. Likewise, the precise role of intracellular AN second messengers, e.g. nicotinic acid adenine dinucleotide phosphate (NAADP) or 3’,5’-cyclic adenosine monophosphate (cAMP), in the spatio-temporal control of signaling processes by forming or modulating microdomains with their metabolizing enzymes, specific binding proteins or receptors, or target ion channels remains largely unknown.
The central goal of the research consortium is to further our understanding of the regulatory roles of AN and their kinetics in the context of inflammatory diseases. Specific aims relate to (i) modulation of the balance between pro- and anti-inflammatory processes by AN converting ecto-nucleotidases and purinergic receptors, and to (ii) AN-driven intracellular calcium signaling and cAMP signaling in inflammation.
NEWS
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SFB1328 Meeting Report: 14th SCSC
From October 11th to 15th, 2026, the 14th International Symposium on Calcium Signaling in China (SCSC) was held in Jinan with two…
PUBLIC OUTREACH
Animal testing is controversial, yet it remains part of modern research. Why do scientists still use animals, and what can we already achieve without…
SFB1328 Meeting Report: 12th ECS Symposium
On September 28, 2026, the 12th European Calcium Society (ECS) Symposium on ‚Calcium Remodeling as a Novel Aging Hallmark‘ was opened by Pilar Garcés…
SFB1328 Meeting Report: 3rd European Purine Meeting
From June 30 to July 3, 2026, the 3rd European Purine Meeting was held in Bordeaux, France. Five members of the SFB 1328, Björn-Ph. Diercks (A02),…
SITE-VISIT
On June 24, 2026, all members of SFB1328 'Adenine Nucleotides in Immunity and Inflammation' attended the dress rehearsal for the on-site visit of the…
For further announcements, see LinkedIn
LATEST PUBLICATION
Schädlich IS, Nguyen DH, Thiem MW, Franzelin A, Woo MS, Hadjilaou A, Borggrewe M, Jiang J, Panda M, Costanzo EM, Fischer T, Er-Lukowiak M, Duan Y, Rissiek A, Veltkamp AW, Raczkowski F, Ludewig P, Schwaninger M, Wirth D, Tiegs G, Oertner TG, Schreier D, Frye M, Sivayoganathan A, Krebs CF, Johann S, Braunger BM, Renné T, Puig B, Wiesner A, Glatzel M, Mittrücker HW, Rissiek B, Magnus T. Endothelial neo-antigen expression initiates CD8⁺ T cell-driven CNS vasculitis amplified by peripheral immune challenge. J Clin Invest. 2026 Oct 20:e205723.
Mayer C, Woo MS, Sonner JK, Binkle-Ladisch L, Fischbach F, Sekol P, Smith MD, Lucas-Ruiz F, Manteufel D, Mattern KM, Pfeffer LK, Guo Y, Siebels B, Miguela A, Vieira V, Meurs N, Bauer S, Schwarz S, Wulf S, Mühlig AK, Engler JB, Conrad M, Bareyre FM, Wiech T, Krasemann S, Glatzel M, Zipfel PF, Freiwald T, Calabresi PA, Schirmer L, Friese MA. Intracellular complement factor H protects neurons during CNS inflammation. Nature. 2026 Sep 2.
Mohammadpour F, Beiersdorfer A, Samad-Yazdtchi K, Hirnet D, Lohr C. Developmental changes in Ca2+signaling mediated by A2A adenosine and mGluR5glutamate receptors in olfactory bulb astrocytes. Sci Rep. 2026 Aug 27;16(1):26939.
Dostiar Tabrizi S, Nawrocki M, Bedke T, Böttcher M, Stumme F, Birus M, Möckl F, Hernandez L, Diercks BP, Gagliani N, Lodygin D, Flügel A, Guse AH, Mittrücker HW, Huber S. Ryanodine Receptor 1 Is Dispensable for CD4+ T-Cell Differentiation and Effector Function in Intestinal Inflammation Models. Eur J Immunol. 2026 Aug;56(8):e70252.
Sandmann M, Tajdar S, Sander S, Ruiz Carrillo D, Ganter B, Fischer C, Ocenas M, Etzold S, Pekarek N, Berger J, Meister TL, Selisko B, Canard B, Watt JM, Baszczyňski O, Potter BV, Garcia Alai M, Tidow H, Pfefferle S, Meier C, Fliegert R. Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2. Nat Commun. 2026 Jul 27;17(1):7416.
